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Doctor's Best Glucosamine Chondroitin MSM 240 Capsules
Doctor's Best Glucosamine Chondroitin MSM 240 Capsules see more from Doctor's Best

Doctor's Best Glucosamine Chondroitin MSM 240 Capsules

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240 Caps
Description

Doctors Best Glucosamine Description

  • Science-based nutrition
  • Dietary supplement
  • Maintains health joints and connective tissue*

Doctor's Best Contains sodium-free potassium stabilized glucosamine sulfate, bovine chondroitin sulfate and pure MSM. (OptiMSM®).

Suggested Adult Use: Take 2 capsules twice daily, with or without food.

Note: Glucosamine is obtained from the shells of shellfish.

Other ingredients: Cellulose, magnesium stearate (vegetable source), gelatin (capsule).

The amount of chondroitin sulfate is verified by CPC Titration testing, using USP Test Method and USP Reference Material (dried).

The Roles of Glucosamine and Chondroitin Sulfate in Joints
Articular cartilage is a connective tissue composed of specialized cells (chondrocytes) embedded in a matrix of protein fibers (mostly collagen) and clusters of complex proteoglycan molecules that consist of a protein core with numerous side chains. These side chains, chiefly chondroitin sulfate and keratin sulfate, are long polysaccharide molecules called glycosaminoglycans. Chondroitin sulfate (CS) and the other glycosaminoglycans strongly attract water due to the negative charges of their sulfate groups. These negative charges also repel each other, creating spaces between glycosaminoglycan side chains where water can enter. This combination of solid and liquid gives cartilage a compressible quality that allows it to function as a shock absorber for joints.

Glucosamine is a fundamental building block for proteoglycans and glycosaminoglycans. Glucosamine sulfate (GS) helps to maintain joint health through its ability to both act as a component of and stimulate formation of cartilage glycosaminoglycans and the hyaluronic acid backbone essential for the formation of cartilage proteoglycans.

The Abundant Evidence Behind Glucosamine and Chondroitin Sulfate

Extensive joint health research over the past few decades has investigated the effects of glucosamine sulfate, chondroitin sulfate, or a combination of the two. A 2009 meta-analysis summarized results from 6 well-designed studies involving a total of 1,502 research participants. The authors of this meta-analysis were able to make some conclusions about the apparent effectiveness of long-term oral supplementation with CS or GS. Glucosamine sulfate at 1,500 mg daily over a period of at least 3 years and chondroitin sulfate at 800 mg daily over a period of at least 2 years both helped subjects maintain healthy knee cartilage structure. In a 2008 review of GS & CS used for joint support, the London physician who wrote it concludes that, “Glucosamine, chondroitin, and the combination of these two agents have stood the test of time.”

Glucosamine sulfate is one of the most important—and thoroughly researched—dietary supplements for joint health ever developed. In addition to its potential to influence joint structure (and thus function), research also backs the ability of GS to influence joint comfort. In one such multicenter, randomized, double-blind, parallel-group study of 252 subjects, joint comfort in the knee was found to be higher in the glucosamine sulfate group than the placebo group.6 Similar studies of equal magnitude found that GS enhanced joint comfort. Key among findings from these types of studies is the reoccurring theme of a good safety profile for glucosamine sulfate; reported “side effects” of GS were essentially no different than placebo.

Similar to glucosamine, chondroitin sulfate is known to influence the maintenance of healthy cartilage—in this case by acting on matrix metalloproteases (MMPs). Chondroitin sulfate has been shown to inhibit MMP-3 synthesis, which plays an important role in homeostasis of cartilage proteoglycans. Additionally, CS can downplay MMP-13 in chondrocytes, helping to maintain the integrity of articular cartilage matrix.

Clinical Trials Explore MSM’s Joint Action
Results from a randomized, double-blind, placebo-controlled pilot trial examining the effect of MSM supplementation on joint comfort in 50 men and women are promising. Subjects taking OptiMSM® methylsulfonylmethane for 12 weeks experienced greater joint comfort than those taking placebo, suggesting potential for MSM as a joint support nutrient that warrants further investigation in larger clinical trials. MSM also produced statistically significant changes in urinary malondialdehyde, a marker of oxidative stress.

MSM has also been used in combination with glucosamine to study their impact on the health of joints. In one such study, a total of 118 subjects were randomized into one of four groups for 12 weeks: glucosamine (500 mg three times daily), MSM (500 mg three times daily), the combination of glucosamine and MSM. Glucosamine alone and MSM alone were shown to enhance joint function, while the combination was found to be even more effective, by both subjective and objective measurements.

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Supplement Facts
Supplement Facts
Serving Size: 2 Capsules
Servings per Container: 120
Amount Per Serving %DV
Chloride (from glucosamine sulfate 2KCI) 84 mg 2%
Sodium (from chondroitin sulfate sodium) 28 mg 1%
Potassium (from glucosamine sulfate 2KCI) 91 mg 3%
Glucosamine sulfate 2KCI 750 mg
Chondroitin sulfate (from chondroitin sulfate sodium) 600 mg
Methylsulfonylmethane OptiMSM® 500 mg
** Percent Daily Values are based on a diet supplying 2000 calories per day.
† Daily Value not established.

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5 Star Rating

Arrived on time but I was at work when it was delivered which is my fault. So I managed to picked it up from my local post office pay for the tax after a week. My hubby I are happy with your product. Highly recommended xxx
5 Star Rating

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5 Star Rating

Was very happy with my order. I received it quickly and it is exactly what I wanted.
5 Star Rating

Superb value. Great service. Recommending Natural Market to friends.
5 Star Rating

I got the Glucosamine/Chondroitin MSM for myself and for my husband. We take it every day. We're starting to see results with ease of movement and decrease in joint pain. I have purchased other natural items from My Natural Market and have never been disappointed with quick delivery and reasonable pricing.


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